Well worth a try for the cost
Crutchfield Customer Review (What's this?)
I bought two kits (four sheets total) and applied a sheet behind each new Polk door speaker in my 2016 Lexus ES350. The sound improvement, even with the base (non Mark Levinson) stereo is impressive! Of course, I can't say for sure how much is the Dynamat and how much are the speakers, but I would use this again for sure for the modest cost. There was a little (4 by 4 inch) piece of Dynamat-like material behind each front door speaker, applied to the inside of the outer door skin, from the factory. So that tells me Toyota/Lexus knew it was needed but they didn't want to spring for much of it. I applied the new sheet over it, and the rear door had none at all. I'm going to remove the hood sound blanket, interior trunk lid trim, and trunk carpet, apply Dynamat, and reinstall them for a factory look. I think some Dynamat in each area will quiet the car even further, it's pretty quiet to start with.
Pros: Gave the doors a more solid sound when closing, speakers sound better with more bass
Cons: Can't think of any so far